LB942 Prospective randomized controlled trial on the effects of almonds on the gut microbiome in association with the gut-skin axis and skin related effects

Almonds are a rich source of fatty acids, phytochemical polyphenols, and antioxidants such as vitamin E. We previously showed that 24 weeks almond consumption significantly decreased facial wrinkle severity pigmentation. Sebum excretion increased in the control group while there was no increase group. Here, we analyze how gut microbiome altered after this may contribute to gut-skin axis. A prospective, randomized, placebo-controlled study included postmenopausal women (n=56) who consumed 20% their daily energy either almonds (n=28) or calorie-matched snacks for weeks. Stool samples were analyzed with whole-genome sequencing detect microbial abundance well functional gene expression. In intervention group, significant Bacteroidetes phylum Butyricimonas virosa (p<0.05), which known short-chain acid producers. The analysis demonstrated an queuosine biosynthesis, glycolysis VI, mannitol cycle, decrease formaldehyde assimilation II (RuMP cycle) superpathway L-serine glycine biosynthesis I (p<0.05). On other hand, snack supplementation augmented glycogen degradation suggesting load glucose agreement content beneficially alter association noted changes skin. Changes also reflect glycemic food interventions.